AMANTADINE What is Amantadine. Amantadine is a medication used to treat abnormal movements in conditions such as Parkinson’s disease. What does Amantadine do in the body. Amantadine has mild effects on dopamine neurons, but we’re not sure exactly how it works for Parkinson’s. It also seems to stop a virus from infecting cells, but we don’t fully understand how it works. While Amantadine has some antiviral properties, it is no longer recommended as an antiviral in clinical practice. [1] How can Amantadine help alleviate certain long COVID symptoms and pathophysiology. When it comes to long COVID, especially post-COVID-19 fatigue, there’s limited but hopeful evidence for using amantadine.